Time Course of Nerve Regeneration and Urethral Dysfunction after Bilateral Pudendal Nerve Injury in Female Rats
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چکیده
Aims of Study Stress urinary incontinence (SUI) is a significant medical problem affecting approximately 25 million Americans of all ages [1]. One of the epidemiologic factors most strongly associated with development of SUI in women is vaginal delivery of children [2], which can injure the nerves, muscles, and connective tissues responsible for maintaining continence [1]. In particular, the pudendal nerve, which innervates the external urethral sphincter (EUS), can be damaged during childbirth [3]. It has been shown previously that a bilateral pudendal nerve crush injury induces symptoms of SUI in female rats [4,5]. The purpose of this study was to determine the time course and extent of pudendal nerve regeneration and urethral dysfunction after a bilateral pudendal nerve crush in female rats.
منابع مشابه
Short-term timecourse of bilateral pudendal nerve injury on leak-point pressure in female rats.
The pudendal nerve innervates the external urethral sphincter and, when injured, can contribute to incontinence development. This experiment was designed to study the time course of functional changes in the urethra after pudendal nerve crush in rats. Leak-point pressure (LPP) was measured 2, 4, 7, or 14 days after bilateral pudendal nerve crush and was compared to that of a control group. LPP ...
متن کاملTime course of neuroanatomical and functional recovery after bilateral pudendal nerve injury in female rats.
The pudendal nerve innervates the external urethral sphincter (EUS) and is among the tissues injured during childbirth, which may lead to symptoms of stress urinary incontinence (SUI). To understand the mechanisms of injury and repair, urethral leak-point pressure (LPP) was measured 4 days, 2 wk, or 6 wk after bilateral pudendal nerve crush. Morphometric changes in the distal nerve and EUS were...
متن کاملPudendal nerve stretch reduces external urethral sphincter activity in rats.
PURPOSE Most animal models of stress urinary incontinence simulate maternal injuries of childbirth since delivery is a major risk factor but they do not reproduce the nerve stretch known to occur during human childbirth. We hypothesized that pudendal nerve stretch produces reversible dysfunction of the external urethral sphincter. MATERIALS AND METHODS Female virgin Sprague-Dawley® rats were ...
متن کاملPudendal nerve injury reduces urethral outlet resistance in diabetic rats.
Diabetics have voiding and continence dysfunction to which elevated levels of advanced glycation end products (AGE) may contribute. In addition, pudendal nerve injury is correlated with voiding dysfunction and stress incontinence in rats. The aim of this study was to investigate whether pudendal nerve crush (PNC) in diabetic rats alters urinary function. Female virgin Sprague-Dawley rats (144) ...
متن کاملExternal urethral sphincter activity in a rat model of pudendal nerve injury.
AIMS Pudendal nerve injury in the rat has been a useful animal model for studying stress urinary incontinence (SUI). However, the effect of pudendal nerve injury on activity of the external urethral sphincter (EUS) is relatively unexplored. The aims of this study were to examine voiding and the EUS electromyogram (EMG) in a durable SUI model in rats with bilateral or unilateral pudendal nerve t...
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